Lysate clarification in nucleic acid purification protocols for target antigen production and antibody humanization include high speed centrifugation runs with up to 20,000 x g. High numbers of temperature-sensitive samples with up to 50 mL need to be processed. Each protocol has multiple centrifugation steps interrupted by pipetting and vessel changes. Refrigerated benchtop Centrifuge 5910 R in combination with low-weight aluminum rotors offer advanced cooling performance for optimal sample protection and reproducibility.