Forensic science plays a crucial role in our legal system with life-changing decisions often based on forensic data. It is a unique scientific discipline that faces unique challenges. Forensic samples are often the most difficult specimens to process. They are typically limited in quality and quantity, can be environmentally exposed, and may require purification from difficult substrates that contain PCR inhibitors. Extensive sample preparation is also required with DNA analysis. Obtaining accurate results from difficult samples is one of many everyday challenges in forensics. Forensic scientists also face intense regulatory requirements, increasing throughput demands and limited resources.