The production of antibodies in cell lines and antigens in bacteria involve harvesting cells from large volume suspensions of several liters. To guarantee sample integrity, cooling is key in these process steps. Refrigerated benchtop Centrifuge 5910 Ri in combination with 4 liter swing-bucket Rotor S-4xUniversal offer advanced cooling performance for optimal sample protection and reproducibility. For improved sustainability and economic efficiency large-volume bottles are reusable, autoclavable, UV-resistant and dishwasher-proof. The new user management including run records optimally supports GxP documentation.