Lysate clarification in nucleic acid purification protocols for target antigen production and antibody humanization include high speed centrifugation runs with up to 20,000 x g. High numbers of temperature-sensitive samples with up to 50 mL need to be processed. Each protocol has multiple centrifugation steps interrupted by pipetting and vessel changes. Refrigerated benchtop Centrifuge 5910 Ri in combination with low-weight aluminum rotors offer advanced cooling performance for optimal sample protection and reproducibility. The new user management including run records optimally supports GxP documentation.