High-throughput screening for the identification of antibody hits in culture supernatants of hybridoma clones is usually performed in microtiter plates (MTPs) with 96 or more wells. Various methods are required and all include multiple centrifugation steps of temperature-sensitive samples in MTPs. Refrigerated benchtop Centrifuge 5920 R in combination with swing-bucket Rotor S-4x1000 with plate/tube buckets offer super-high capacity of up to 28 MTPs per run and an advanced cooling performance for optimal sample protection.