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- Challenges and Chances: A Review of the 1st Stem Cell Community Day
- Summertime, and the Livin’ Is Easy…
- Follow-on-Biologics – More than Simple Generics
- Bacteria Versus Body Cells: A 1:1 Tie
- Behind the Crime Scene: How Biological Traces Can Help to Convict Offenders
- Every 3 Seconds Someone in the World Is Affected by Alzheimer's
- HIV – It’s Still Not Under Control…
- How Many Will Be Convicted This Time?
- Malaria – the Battle is Not Lost
- Physicians on Standby: The Annual Flu Season Can Be Serious
- At the Forefront in Fighting Cancer
- Molecular Motors: Think Small and yet Smaller Again…
- Liquid Biopsy: Novel Methods May Ease Cancer Detection and Therapy
- They Are Invisible, Sneaky and Disgusting – But Today It’s Their Special Day!
- How Many Cells Are in Your Body? Probably More Than You Think!
- What You Need to Know about Antibiotic Resistance – Findings, Facts and Good Intentions
- Why Do Old Men Have Big Ears?
- The Condemned Live Longer: A Potential Paradigm Shift in Genetics
- From Research to Commerce
- Chronobiology – How the Cold Seasons Influence Our Biorhythms
- Taskforce Microbots: Targeted Treatment from Inside the Body
- Eyes on Cancer Therapy
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- Services pour pipettes
- Services pour centrifugeuse et rotors
- Services pour Mastercycler
- Services pour automates de pipetage
- Services pour bioprocédés
- Services pour congélateurs
- Services pour incubateurs
- Services pour agitateurs
- Services pour appareils de photométrie
- Service de contrôle de la température et de l’agitation
- Services pour la manipulation cellulaire
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- Challenges and Chances: A Review of the 1st Stem Cell Community Day
- Summertime, and the Livin’ Is Easy…
- Follow-on-Biologics – More than Simple Generics
- Bacteria Versus Body Cells: A 1:1 Tie
- Behind the Crime Scene: How Biological Traces Can Help to Convict Offenders
- Every 3 Seconds Someone in the World Is Affected by Alzheimer's
- HIV – It’s Still Not Under Control…
- How Many Will Be Convicted This Time?
- Malaria – the Battle is Not Lost
- Physicians on Standby: The Annual Flu Season Can Be Serious
- At the Forefront in Fighting Cancer
- Molecular Motors: Think Small and yet Smaller Again…
- Liquid Biopsy: Novel Methods May Ease Cancer Detection and Therapy
- They Are Invisible, Sneaky and Disgusting – But Today It’s Their Special Day!
- How Many Cells Are in Your Body? Probably More Than You Think!
- What You Need to Know about Antibiotic Resistance – Findings, Facts and Good Intentions
- Why Do Old Men Have Big Ears?
- The Condemned Live Longer: A Potential Paradigm Shift in Genetics
- From Research to Commerce
- Chronobiology – How the Cold Seasons Influence Our Biorhythms
- Taskforce Microbots: Targeted Treatment from Inside the Body
- Eyes on Cancer Therapy
-
-
- Services pour pipettes
- Services pour centrifugeuse et rotors
- Services pour Mastercycler
- Services pour automates de pipetage
- Services pour bioprocédés
- Services pour congélateurs
- Services pour incubateurs
- Services pour agitateurs
- Services pour appareils de photométrie
- Service de contrôle de la température et de l’agitation
- Services pour la manipulation cellulaire
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Stem Cell Bioprocessing
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Culture standardization and efficient scale-up
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Cultivation of cell aggregates
For many applications like disease modeling, drug toxicity assessment, and manufacture of stem cell-based products, three-dimensional (3D) cell aggregates are of great interest. Researchers at the Instituto de Biologia Experimental e Tecnológica (iBET) in Portugal have tested the suitability of the Eppendorf DASbox® Mini Bioreactor System for the cultivation of the human tumor cell line H157 as 3D cell aggregates.

Controlled Cultivation of Stem Cells - Factors to Consider When Thinking of Scale-Up
Widely established in traditional cell culture, controlled bioreactors have the potential to establish reproducible expansion of stem cells. They provide extensive options for monitoring and control of key parameters such as pH and dissolved oxygen in real-time and facilitate a controlled differentiation of the cells. Through scalable bioreactor design, results obtained in small scale can be transferred to larger working volumes while maintaining optimum mass transfer.
- Download poster
- Download white paper: Controlled Cultivation of Stem Cells
- Download infographic: Stem Cell Expansion in Bioreactors
- Listen to podcast: Scaling up Cell Therapy Manufacture

Interview with Dr. Philipp Nold
Dr. Nold joined the Eppendorf Bioprocess Center as an Infield Application Specialist for stem cells. In this interview he speaks about the latest advances in bioprocessing.
Main aspect of this interview is: Biopharma know-how meets bioreactor innovation in upstream bioprocessing.
Click here to read the interview

Induced pluripotent stem cells
Since the pioneering development of cell reprogramming by Shinya Yamanaka in 2006, induced pluripotent stem cells (iPSCs) have risen to be the most promising alternative to ethically problematic embryonic stem cells. Controlled cultivation and scale-up in clinical grade as well as ways to control their differentiation towards their final destiny will be key steps towards commercial use of these cells.
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Dr. Robert Zweigerdt and his team at Hannover Medical School are investigating human pluripotent stem cell culture for clinical use. They established a process using the Eppendorf DASbox® Mini Bioreactor System equipped with BioBLU® Single-Use Vessels. As part of the EU-funded research project TECHNOBEAT , Eppendorf and the Hannover Medical School aim at scaling up the culture and develop a GMP-compliant process.
- Watch webinar: Controlling Expansion and Cardiomyogenic Differentiation
- Download application note: Scalable Expansion of Human Pluripotent Stem Cells
- Download press release: EU funds Stem Cell Technologies for Heart Repair (TECHNOBEAT)

Stem Cell Community Day
The Stem Cell Community Day connects researchers from all over the world to review recent advances in the area of stem cells, with a special focus on cultivation in stirred-tank bioreactors.


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eBook: Advancing medicine - Can cell and gene therapies paint a picture of perfect future health?
(The Medicine Maker, sponsored by Eppendorf)
3.2 MB, PDF

A selection of our customers





Eppendorf SE
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