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Exosome Production

Bioreactor system and centrifuge for large-scale exosome production and purification
Exosomes are naturally occurring extracellular vesicles secreted by cells with the primary function of carrying molecular payloads such as proteins or genetic material between cells. In doing so, exosomes have the ability to modulate cell communication, immune regulatory processes, tumor metabolism, and regenerative/degenerative processes. They have recently become of great interest for their use as therapeutic and diagnostic tools. Research into exosomes in the preclinical cell and gene therapy (CGT) space is growing rapidly. The ever-greater need for industry-scale exosome production requires exosome process development efforts to meet the demands of research and development projects. The use of stirred-tank bioreactors for upstream expansion represents one of the best approaches to ensuring optimal exosome production conditions and enabling tight monitoring and control of the bioprocess in a highly scalable setup. The use of centrifuges is considered the gold standard for the purification of exosomes from the culture medium.

Strategies for large-scale exosome production

Now gaining traction, the use of exosomes for cell and gene therapy applications is increasingly reliant upon the production of high amounts of high-quality exosomes. As with every cell culture process, the exosome upstream expansion workflow presents numerous opportunities to introduce variability, and this can lead to poor yield and batch inconsistencies. In comparison with conventional 2D culture platforms, bioreactors offer numerous advantages to control the cells’ growth environment and increase the working volume. Like this they are valuable tools for exosome process development to produce exosomes in a scalable and reproducible manner.

Article collection: Exosome Production, Isolation and Applications

This collection emphasizes the critical role of production and isolation techniques in developing new diagnostic tools and therapies for diverse diseases. It showcases production of exosomes, engineering of exosomes for immunotherapy, advances in in their use as biomarkers for cancer and exosome isolation techniques to help researchers to fully explore their potential.

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How are exosomes utilized in the cell and gene therapy field?

Gene therapy vectors‌

Regenerative medicine‌

Discover our products for exosome production

Discover our bioreactor control systems and centrifuges for exosome process development, scale-up of exosome production, and exosome purification.

Incubators for the pre-culture of cells‌

Bioreactors for process development and small-scale production‌

Bioreactors for scaling up exosome production‌

Centrifuges for the purification of exosomes‌

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Select the right bioprocess equipment

Are you interested in cultivating exosome-producing cells? Please contact us to discuss the needs of your individual application.

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Select the right centrifuge, incubator, and shaker

Would you like to know more about our shakers and incubators or our centrifuge solutions for the purification of exosomes? Contact us for more information.

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Eppendorf bioprocess solutions for your applications

Visit our main bioprocessing website to discover our bioprocess solutions for various industries and applications.