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CelliGen 510
Cell Culture Impellers
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Product Information
SIP benchtop reactors designed to meet the needs of R&D through production.You will find additional download material at the bottom of this page
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Product Information
Applications
Features
Product Information
The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.
Gas flow
• Various combinations of one, two, three or four TMFCs:
0.06 – 3 SLPM
0.3 – 15 SLPM
0.6 – 32 SLPM
1 – 64 SLPM
• Air Wash System with TMFC (0 – 15 or 0 – 32 SLPM)
• Overlay with TMFC (0 – 15 or 0 – 32 SLPM)
• Overlay (valve only)
Exhaust line
• Exhaust condenser
• Manual or automatic pressure control
Impellers
• Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired.
• Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing. Provided as standard with the CelliGen 510 bioreactors.
• Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing
• Spinfilter – For suspension or microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste
• Cell-Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures
• Packed-bed – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel® Disks to provide extremely high cell densities
Sensors
• Single or redundant pH/DO
• Redox
• Foam/level
Addition and sampling
• Resterilizable sampling valve
• Resterilizable addition valves (4 max)
• Resterilizable addition/harvest valve with dip tube (2 max)
• 1.5 in sanitary fitting 7-port septum
• Addition vessels (glass/stainless steel)
• Decanters
• Sterile sampling assembly
Validation
• Basic Package
• Basic Plus Package
• Enhanced Package
Utility regulator & pre-filter kits
• Process air pre-filter/regulator kit
• Instrument air pre-filter/regulator kit
• Water pre-filter/regulator kit
• Process steam regulator kit
• Utility steam pre-filter/regulator kit
• Utility connection kit
Additional options
• Sprayballs for clean-in-place of vessel
• External variable-speed pumps
• External scales
• Spare parts kits
• Preventative maintenance kits
• Mobile table
• System passivation
• Glycol/chiller heat exchanger
Gas flow
• Various combinations of one, two, three or four TMFCs:
0.06 – 3 SLPM
0.3 – 15 SLPM
0.6 – 32 SLPM
1 – 64 SLPM
• Air Wash System with TMFC (0 – 15 or 0 – 32 SLPM)
• Overlay with TMFC (0 – 15 or 0 – 32 SLPM)
• Overlay (valve only)
Exhaust line
• Exhaust condenser
• Manual or automatic pressure control
Impellers
• Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired.
• Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing. Provided as standard with the CelliGen 510 bioreactors.
• Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing
• Spinfilter – For suspension or microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste
• Cell-Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures
• Packed-bed – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel® Disks to provide extremely high cell densities
Sensors
• Single or redundant pH/DO
• Redox
• Foam/level
Addition and sampling
• Resterilizable sampling valve
• Resterilizable addition valves (4 max)
• Resterilizable addition/harvest valve with dip tube (2 max)
• 1.5 in sanitary fitting 7-port septum
• Addition vessels (glass/stainless steel)
• Decanters
• Sterile sampling assembly
Validation
• Basic Package
• Basic Plus Package
• Enhanced Package
Utility regulator & pre-filter kits
• Process air pre-filter/regulator kit
• Instrument air pre-filter/regulator kit
• Water pre-filter/regulator kit
• Process steam regulator kit
• Utility steam pre-filter/regulator kit
• Utility connection kit
Additional options
• Sprayballs for clean-in-place of vessel
• External variable-speed pumps
• External scales
• Spare parts kits
• Preventative maintenance kits
• Mobile table
• System passivation
• Glycol/chiller heat exchanger
Applications
- Laboratory- and pilot-scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
- Laboratory- and pilot-scale cell culture of mammalian, insect, and human cell lines
- Special applications such as stem cell culture, vaccine, monoclonal antibody or biofuel/biopolymer production
- Suitable for batch, fed-batch, and continuous/perfusion processes
Features
- RPC (Reactor Process Control) software
- 32 L stainless-steel electropolished vessels with 2:1 aspect ratios
- Integrated load cell
- 3-Fixed speed peristaltic pumps for the additions, harvest, and pH control
- Benchtop or Mobile option
- Choice of pitched-blade, marine, spin filter, cell-lift or packed-bed impellers
- industrial touchscreen interface