The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has revealed virtually all environments, including the human body, are teeming with diverse microbial communities. While scientists study microbes largely in the context of pathogenicity, it is now evident that human microbiota contribute biological functions essential to health. Conversely, disrupting microbiota homeostasis in healthy individuals can lead to dysbiosis and is associated with many diseases and pathologies.
As a consequence, research into the human microbiome offers the potential to transform the healthcare landscape and provide novel diagnostics and therapeutics. Other aspects similarly impacted by metagenomics include biological safety of food and water. In agriculture, changes in soil and in animal microbiomes can now be evaluated in a context of crop yield, livestock health, and reduced dependency on herbicides, pesticides, and antibiotics. Transformative applications of microbiome sequencing in diagnostics, drug development, public health, agriculture, and water safety will be discussed.
Key learning objectives:
- How to standardize NGS library preparation
- Premises for reliable microbiome data
- How to implement laboratory automation in your lab
Rita Colwell, PhD, University Professor at the University of Maryland at College Park and President of CosmosID, Inc
Christiane Honisch, PhD, Global Head Business Intelligence and Development, Eppendorf AG