Inactivated vaccines
Inactivated vaccines (e.g., for hepatitis A, rabies, polio) still carry the full repertoire of immunogenic components of the original pathogen. Proper inactivation is mandatory to avoid viral reactivation and replication in the host.
➕ Pathogen inactivation by radiation, heat, or chemical reagents ensures a superior safety profile and advantages in terms of transport and storage.
➖ Require processing of large quantities of the pathogen. The inactivation process can affect the antigen immunogenicity. As the antibody titers reduces over time, several booster doses are needed.
Live-attenuated vaccines
Repeated subculturing in a foreign host belongs to the most common methods to obtain attenuation of live-attenuated vaccines (e.g., for variola virus, measles virus, rotavirus). With each passage, the virus becomes less virulent. The native viral antigen conformation is still preserved, mimicking the natural infection without causing disease.
➕ Usually produce long-lasting robust cellular and humoral immune responses with only one administration.
➖ Safety issues in immunosuppressed people may occur, weakened strains are difficult to obtain, development time is long, and refrigeration obligatory.
Safe and consistent culturing of cells
The CellXpert® C170i offers fast temperature and CO2 recovery (< 5 min/s) and very stable environmental conditions for (e.g) virus host cells as well as reliable contamination prevention (e.g. 180 °C sterilization).
Thousands of PCRs in as little as 15 mins
Large numbers of PCRs are required to amplify viral genomic information prior to sequencing. The Mastercycler® X50 with the 384-well silver block can process hundreds of PCRs in as little as 40 min and with a fast polymerase kit even in less than 15 min. Connect up to 50 devices for increased throughput.
Ensure optimal assay performance
Eppendorf Plates® LoBind® ensure maximum sample recovery during quantitative assays. They can be customized with barcodes for efficient sample tracking and are available printed with their LOT number.
Speed up In Vitro Screening assays.
The Eppendorf Xplorer® enables quick filling of plates using the dispensing mode. When connected to the Pipette Manager, an even quicker operation of the pipette is possible.
Ensure optimal assay performance
The LoBind® material guarantees maximum sample retrieval for sensitive assays. It also demonstrates low virus binding activities. LoBind tubes are free of surface coating for lowest contamination risk.
Automate your repetitive, routine tasks.
With the Eppendorf epMotion® you can use a variety of kits. The epMotion has an intuitive drag-and-drop-based software and full consumable flexibility.
Reproducible PBMC isolation
The 5910 Ri centrifuge has soft acceleration/break ramps to for optimized PBMC isolation during Ficoll gradient separation and reduced stress on sensitive immune cells used in immunology assays.
Smart and safe sample storage
Safe Code Vials enable next level traceability when storing your mRNA at -80°C. Get ID-specific consumable information for comprehensive documentation during your R&D phase. The ACT certified CryoCube freezers ensure energy efficiency and sample safety.
*All products are for Research Use Only (RUO).
The most novel vaccines: Nucleic acid vaccines
Nucleic acid vaccines are made up of mRNA or plasmid DNA encoding viral antigenic components to express specific proteins of a pathogen after injection. The advantages are manifold.
Strong growing vaccines: Recombinant protein vaccines
Protein subunit vaccines as for influenza or hepatitis B and C are a proven strategy for decades and still today in the spotlight for pandemic management.
