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Bioprocess Autosampler

Product Information

The Bioprocess Autosampler takes samples from multiple bioreactors and stores them tempered for later analysis or transfers them to an integrated at-line cell culture analyzer. It supports automated sampling, inoculation, and bolus addition, while enabling parameter-based process adjustments. The result is greater process insight, improved control, and reduced manual effort. The Bioprocess Autosampler is compatible with glass and single-use bioreactors operated with a DASbox® Mini Bioreactor System, DASGIP® Parallel Bioreactor System, SciVario® twin or BioFlo® 320/BioFlo 320 plus bioreactor control system.

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    Bioprocess Autosampler
    • base unit, single head, with accessories
    • for 4 vessels, 1.6 m
    More Product Details ...
    Catalog no. 7700200007

      Bioprocess Autosampler
      • base unit, dual head, with accessories
      • for 8 vessels, 2.0 m
      More Product Details ...
      Catalog no. 7700200008

      Product Information
      Applications
      Features
      Automated Sampling: Better Bioprocess Data and Better Process Control with Less Effort:

      You often need to sample your culture during the bioprocess, not just at the end. These samples help you monitor growth, product formation, and nutrient consumption. This way, you can identify interdependencies and take action at predefined times or specific events. The Bioprocess Autosampler from Eppendorf provides this solution to you. Whether you are working in cell culture or fermentation, in early R&D or process development, and using single-use or glass bioreactors, this system covers it all. The Bioprocess Autosampler can handle sampling and bolus addition at short, regular intervals, helping you gain complete datasets and automate bioprocess control.


      Samples can be automatically stored tempered for later analysis. For cell culture application, they can also be automatically transferred to an integrated analyzer, enabling at-line analysis of the critical process parameters within minutes. With the DASware® control software, the results can be used for feedback-loop control of your process. This allows for a direct response to your process without operator presence.

      Automated sampling


      • Facilitates sampling 24/7 in regular, short intervals
      • Time is freed up for other tasks
      • Automated sample storage reduces risk for human error

      Sampling Procedure


      • The Bioprocess Autosampler holds one sampling port per bioreactor
      • Tubing connects the sampling port with a dip tube in the bioreactor
      • Sampling ports harbor a septum, which preserves the sterility of the bioreactor
      • For sampling, a needle connected to a syringe is automatically inserted into the port, pinching through the septum
      • The sample is transferred to a sampling vial by pinching through a septum in the vial lid
      • Samples can be transferred to a tempered storage as well as transferred to an at-line analyzer.

      Compatible Small Scale Bioprocess Control Systems


      The Bioprocess Autosampler can be installed with new as well as retrofitted to existing small scale bioreactor control systems.

      DASbox® Mini Bioreactor System
      • Autosampling of up to 16 bioreactors
      • Compatible with glass and single-use bioreactors
      • Working volume: 60 – 250 mL

      DASGIP® Parallel Bioreactor System
      • Autosampling of up to 16 bioreactors
      • Compatible with glass and single-use bioreactors
      • Working volume: 200 mL – 1.8 L

      Compatible Bench Scale Bioprocess Control Systems


      The Bioprocess Autosampler can be installed with new as well as retrofitted to existing bench scale bioreactor control systems.

      SciVario® twin
      • Autosampling of up to 8 bioreactors
      • Compatible with glass and single-use bioreactors
      • Working volume: 200 mL – 10 L

      BioFlo® 320/BioFlo 320 plus
      • Autosampling of up to 4 bioreactors
      • Compatible with glass and single-use bioreactors
      • Working volume: 320 mL – 10.5 L

      Analyzer integration


      For cell culture applications, samples taken from the bioreactors can be directly transferred to the Nova Biomedical® BioProfile® FLEX2 analyzer:
      • Analysis in minutes for critical process parameters such as glucose, lactate, and glutamate
      • Total cell density and viable cell density to monitor the growth and quality of the cells
      • Osmolality, pH and pCO2/pO2 to monitor culture conditions that influence the growth of the cells