Automated sampling: better bioprocess data and better process control with less effort:
You often need to sample your culture during the bioprocess, not just at the end. These samples help you monitor growth, product formation, and nutrient consumption. This way, you can identify interdependencies and take action at predefined times or specific events. The Bioprocess Autosampler from Eppendorf provides this solution to you. Whether you are working in cell culture or fermentation, in early R&D or process development, and using single-use or glass bioreactors, this system covers it all. The Bioprocess Autosampler can handle sampling and bolus addition at short, regular intervals, helping you gain complete datasets and automate bioprocess control.
Samples can be automatically stored tempered for later analysis. For cell culture application, they can also be automatically transferred to an integrated analyzer, enabling at-line analysis of the critical process parameters within minutes. With the DASware® control software, the results can be used for feedback-loop control of your process. This allows for a direct response to your process without operator presence.
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Bioprocess Autosampler
Bioprocess Autosampler dual head system, 4x DASbox, bottles side, front view, cropped
Bioprocess Autosampler:
소규모 및 벤치 스케일 바이오프로세스 시스템을 위한 모듈형 자동 샘플링 솔루션
소규모 및 벤치 스케일 바이오프로세스 시스템을 위한 모듈형 자동 샘플링 솔루션
Bioprocess Autosampler connection of vessel to multi port module 3
Bioprocess Autosampler sample storage 1
Efficient sampling from bioreactors of different sizes. Different sample sizes with aseptic operation and low dead volume.
Bioprocess Autosampler tool stations and multi port modules, angled bottom view
Bioprocess Autosampler dual head system, 2x DASbox, front view 1
Bioprocess Autosampler dual head system, 2x DASGIP Parallel System, front view 1
The Bioprocess Autosampler takes samples from multiple bioreactors and stores them tempered for later analysis or transfers them to an integrated at-line cell culture analyzer. It supports automated sampling, inoculation, and bolus addition, while enabling parameter-based process adjustments. The result is greater process insight, improved control, and reduced manual effort. The Bioprocess Autosampler is compatible with glass and single-use bioreactors operated with a DASbox® Mini Bioreactor System, DASGIP® Parallel Bioreactor System, SciVario® twin or BioFlo® 320/BioFlo 320 plus bioreactor control system.
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Products (2)
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2 Products
Bioprocess Autosampler
Catalog no.
7700200007
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Bioprocess Autosampler
Catalog no.
7700200008
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Automated sampling
• Facilitates sampling 24/7 in regular, short intervals
• Time is freed up for other tasks
• Automated sample storage reduces risk for human error
Sampling Procedure
• The Bioprocess Autosampler holds one sampling port per bioreactor
• Tubing connects the sampling port with a dip tube in the bioreactor
• Sampling ports harbor a septum, which preserves the sterility of the bioreactor
• For sampling, a needle connected to a syringe is automatically inserted into the port, pinching through the septum
• The sample is transferred to a sampling vial by pinching through a septum in the vial lid
• Samples can be transferred to a tempered storage as well as transferred to an at-line analyzer.
Compatible Small Scale Bioprocess Control Systems
The Bioprocess Autosampler can be installed with new as well as retrofitted to existing small scale bioreactor control systems.
DASbox® Mini Bioreactor System
• Autosampling of up to 16 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 60 – 250 mL
DASGIP® Parallel Bioreactor System
• Autosampling of up to 16 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 200 mL – 1.8 L
Compatible Bench Scale Bioprocess Control Systems
The Bioprocess Autosampler can be installed with new as well as retrofitted to existing bench scale bioreactor control systems.
SciVario® twin
• Autosampling of up to 8 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 100 mL – 10 L
BioFlo® 320/BioFlo 320 plus
• Autosampling of up to 4 bioreactors
• Compatible with glass and single-use bioreactors
• Working volume: 320 mL – 10.5 L
Analyzer integration
For cell culture applications, samples taken from the bioreactors can be directly transferred to the Nova Biomedical® BioProfile® FLEX2 analyzer:
• Analysis in minutes for critical process parameters such as glucose, lactate, and glutamate
• Total cell density and viable cell density to monitor the growth and quality of the cells
• Osmolality, pH and pCO2/pO2 to monitor culture conditions that influence the growth of the cells
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The Bioprocess Autosampler from Eppendorf is designed for bioprocess applications that require automated sampling, bolus additions, and at-line analyzer integration.
- Research and development in microbiology and cell culture
- Suitable for aerobic and anaerobic bacteria and yeasts, as well as mammalian cell lines
- Suitable for small scale and bench scale bioprocess control systems
- Suitable for batch, fed-batch, and continuous processes
The Bioprocess Autosampler from Eppendorf simplifies bioprocess sampling with flexible, efficient, and aseptic operation, a space-saving design, easy installation, and seamless software integration.
- Aseptic operation without the use of a laminar flow cabinet
- Compatible with differently-sized glass and BioBLU® Single-Use Bioreactors with working volumes of 60 mL to 10 L
- Suitable for 1.5 mL and 10 mL sample vials, up to 648 samples can be stored
- Enables regular sampling 24/7, with transfer to the tempered sample storage (between 4 and 40 °C) or transfer to an at-line cell culture analyzer
- Bolus addition is available as an option, to add key components or inoculum
- Sampling and bolus additions can be performed either at a pre-defined time or event-based through the scripting feature in the software
- Low dead volume minimizes the reduction of culture volume
- Feedback loop control based on the results from the integrated analyzer
- Modular design that facilitates expansion of the number of bioreactors to be sampled and retrofitting of existing bioprocess systems
- Sanitation procedure using ethanol is similar to procedures usually applied when sampling manually
- Control of the Bioprocess Autosampler is integrated in DASware® control bioprocess software
Downloads: Bioprocess Autosampler
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