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GMP info

Regarding suitability of Eppendorf bioprocess equipment in GMP-regulated applications, please reach out to your Eppendorf sales representative.

Monoclonal Antibody Production

Monoclonal antibody production using scalable bioprocess systems
Monoclonal antibody-based immunotherapy is a dominant and growing industry producing a promising class of therapeutics such as targeted anticancer drugs. In order to stay competitive, it’s essential that production can be made more efficient and cost-effective whilst still improving upon quality and concentration. Here you can find out how Eppendorf can help you to optimize your bioprocess for monoclonal antibody (mAb) production.
Monoclonal antibodies are genetically engineered molecules that are designed to act as substitute antibodies and restore, improve, alter, or mimic the immune system's defense against undesirable cells, such as cancer cells. Originally, for monoclonal antibody production mAb-producing cells (hybridomas) were generated by fusing immortal myeloma cells with antibody-producing B cells. Today, Chinese Hamster Ovary (CHO) cells are often used as an expression system. Antibody production in bacteria or yeast offers greater speed, however there are challenges associated with glycosylation. Find out more about antibody production in our infographic.

mAB discovery workflow

Antibody development is not without its challenges. Research teams are under increasing pressure to produce specific, high-quality therapeutic treatments within ever-tighter time and budget restrictions. As such, it is essential to optimize each step of the monoclonal antibody production process, from transfection, to clone selection, to process control and scale-up. From choosing candidate cell lines to scale-up, Eppendorf can help you to maintain a competitive edge by providing the tools, expertise, and knowledge needed to improve and regulate antibody yield and quality.

mAB discovery workflow

Choose the right bioreactor system for monoclonal antibody production

Get to know more about cell culture in bioreactors and learn more about the Eppendorf solutions for upstream bioprocessing.

Parallel, small-scale bioprocess systems‌

Parallel small-scale bioreactor systems like the DASbox® Mini Bioreactor System support customers in implementing QbD principles in their development phase. These high-throughput bioreactor systems are designed for parallel cultivations, making them ideal for experimental design, parallel comparison studies and downscaling experiments.

Parallel small-scale bioreactor system, which supports users in implementing QbD principles

Single-use bioreactors‌

From small scale to pilot production scale‌


How our customers use our products

Find some examples of how our customers use Eppendorf bioprocess equipment for monoclonal antibody production.