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GMP info

Regarding suitability of Eppendorf bioprocess equipment in GMP-regulated applications, please reach out to your Eppendorf sales representative.

Microbial Production

Bioreactor control systems for microbial production of proteins, peptides, plasmids, and small molecules

What is microbial production used for?

A variety of microbes can produce valuable molecules for use in medicine, agriculture, and the production of chemicals and food. Small molecules including plasmids, proteins, peptides, and amino acids are commonly generated through microbial fermentation in bacteria, yeast or other fungi. Microbial fermentation–based production has many benefits:
  • Fast development
  • Excellent yields and quality
  • Rapid scalability
  • Low to medium production costs

Read more about bacterial fermentation and yeast fermentation .

What properties make a bioreactor system suitable for microbial production?

Strain selection, choice of media, process development and scale up are all key to maximizing the productivity of your fermentation process. Suitable bioreactors need to be able to facilitate these procedures to produce high quality and optimal yield of the desired products. Here, we will describe how the right bioreactor can enable optimal cell growth and eventual scale-up.

Bioreactors should support high cell densities during aerobic fermentation

Oxygen supply: Essential for an aerobic cultivation to be successful‌

Culture feeding: Needed to encourage growth and microbial production‌

Temperature: Must be monitored and adjusted when necessary‌

Bioprocess systems should facilitate process optimization

How parallel bioreactor systems can help accelerating process optimization‌

How single-use bioreactors can help saving development time‌

How to optimize bioprocess monitoring and control‌

Bioreactors should support scale-up

How to scale-up your bioprocess‌

Bioprocess scale-up with the Eppendorf bioreactor systems‌

Scalable from 60 mL to 2,400 L, Eppendorf offers a wide range of bioreactor control systems to help you scale up from the bench to industrial production:

Bioprocess systems for scaling up microbial production
Read, how we scaled-up an E. coli fermentation process from 1 L to 100 L!

If needed, bioreactors should support microaerobic and anaerobic fermentation

Bioprocessing under anaerobic, microaerobic, and aerobic conditions‌

How our customers use our products

Find some examples of how our customers use Eppendorf bioprocess equipment for microbial fermentation.