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Stem Cell Bioprocessing
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Culture standardization and efficient scale-up
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Cultivation of cell aggregates
For many applications like disease modeling, drug toxicity assessment, and manufacture of stem cell-based products, three-dimensional (3D) cell aggregates are of great interest. Researchers at the Instituto de Biologia Experimental e Tecnológica (iBET) in Portugal have tested the suitability of the Eppendorf DASbox® Mini Bioreactor System for the cultivation of the human tumor cell line H157 as 3D cell aggregates.

Controlled Cultivation of Stem Cells - Factors to Consider When Thinking of Scale-Up
Widely established in traditional cell culture, controlled bioreactors have the potential to establish reproducible expansion of stem cells. They provide extensive options for monitoring and control of key parameters such as pH and dissolved oxygen in real-time and facilitate a controlled differentiation of the cells. Through scalable bioreactor design, results obtained in small scale can be transferred to larger working volumes while maintaining optimum mass transfer.
- Download poster
- Download white paper: Controlled Cultivation of Stem Cells
- Download infographic: Stem Cell Expansion in Bioreactors
- Listen to podcast: Scaling up Cell Therapy Manufacture

Interview with Dr. Philipp Nold
Dr. Nold joined the Eppendorf Bioprocess Center as an Infield Application Specialist for stem cells. In this interview he speaks about the latest advances in bioprocessing.
Main aspect of this interview is: Biopharma know-how meets bioreactor innovation in upstream bioprocessing.
Click here to read the interview

Induced pluripotent stem cells
Since the pioneering development of cell reprogramming by Shinya Yamanaka in 2006, induced pluripotent stem cells (iPSCs) have risen to be the most promising alternative to ethically problematic embryonic stem cells. Controlled cultivation and scale-up in clinical grade as well as ways to control their differentiation towards their final destiny will be key steps towards commercial use of these cells.
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Dr. Robert Zweigerdt and his team at Hannover Medical School are investigating human pluripotent stem cell culture for clinical use. They established a process using the Eppendorf DASbox® Mini Bioreactor System equipped with BioBLU® Single-Use Vessels. As part of the EU-funded research project TECHNOBEAT , Eppendorf and the Hannover Medical School aim at scaling up the culture and develop a GMP-compliant process.
- Watch webinar: Controlling Expansion and Cardiomyogenic Differentiation
- Download application note: Scalable Expansion of Human Pluripotent Stem Cells
- Download press release: EU funds Stem Cell Technologies for Heart Repair (TECHNOBEAT)

Stem Cell Community Day
The Stem Cell Community Day connects researchers from all over the world to review recent advances in the area of stem cells, with a special focus on cultivation in stirred-tank bioreactors.


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eBook: Advancing medicine - Can cell and gene therapies paint a picture of perfect future health?
(The Medicine Maker, sponsored by Eppendorf)
3.2 MB, PDF

Eppendorf SE
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