How many parameters can I control using a DASGIP or DASbox system?

DASGIP Parallel Bioreactor Systems provide comprehensive concurrent monitoring and control of process parameters. During the process run, events are logged together with up to 70 online process variables per bioreactor. In addition to the various DASGIP modules for monitoring and control, with DASware analyze users can integrate analytical devices provided by third parties. Seamless integration into the DASGIP or DASbox system even allows for closed loop solutions such as automated feeding strategies based on the current glucose concentration. Each process value can be used as a trigger enabling users to automate their process.

How many parameters can be displayed in a process overview in DASware control?

DASware control users can freely select all relevant process variables of all or selected bioreactors to be displayed in one chart. There are no limitations in the number of process parameters. When using DASware analyze, the displayed process parameters even include integrated data from third party laboratory devices, such as nutrient analyzers, mass spectrometers or Raman. The software features tables and trend graphs of all measured values. It continuously logs and stores all data and events. These data are immediately accessible for evaluation using e.g. Microsoft Excel. Advanced charting functionalities ease further data analysis and comparison of runs.

Do I need programming skills to automate my process in DASware control?

DASware control includes a set of easy to implement automation features without any need of programming. Profiles and triggers allow for various control strategies, all of them easy to select by mouse click with parameters entered manually or just copy-pasted. Users with programming skills and special control requirements, however, are free to run scripted control strategies and profiles as well.

Can I change triggers, profiles, cascades and scripts online in DASware control?

Set-points, profiles, cascades, and scripts are online editable in DASware control. Offline values and events can be entered during or after the run and documented with a time stamp. These time stamps can be set individually, e.g to meet the time, when the sample was taken. This provides users with great flexibility to interact with the control system and reconsider parameter settings even in highly automated processes. All events, including online changes, are recorded in a SQL Server database.

How difficult is it to modify a DASGIP system subsequently?

Due to the unique modular design of the DASGIP Parallel Bioreactor System upgrades and modifications can easily be done: Functions like OD monitoring, exhaust analysis or extra feed lines can be added as modules to the control system. It is just as easy to substitute the bioreactor type or to upgrade a 4-vessel system to eight vessels. Actually, system modifications are that simple, some customers even share specific modules. For instance, the DASGIP GA4 exhaust analyzer is renowned for being moved from one bioreactor system to another. Like this, it delivers reliable in-depth analysis of OTR, CTR, and RQ for many bioreactors on demand.

How many speed-controlled pumps do the DASGIP bioreactors feature?

Up to eight peristaltic speed-controlled pumps per vessel offer continuous flow rates from 0.3 mL/h - 5 L/h. Each pump can be operated independently. Two different pump head sizes for the multi pump modules DASGIP MP4 and MP8, fitting various tube sizes make the DASGIP multi pumps a flexible and accurate solution.

How are DASGIP vessels agitated?

DASGIP bioreactors feature powerful overhead drives with agitation speeds ranging 30 – 1,600 rpm. The DASGIP TC4SC4 controls temperature and agitation in up to four bioreactors. Users can individually define each outlet set-point as well as choose from different operation modes (e.g. continuous or interval agitation).

Can I integrate DASGIP with my existing historians & supervisory control?

Yes, with the software DASware connect an optional server allows corporate-wide exchange of all process data via seamless integration with historians and supervisory control systems such as Delta V, OSI Pi, etc. This includes events, set-up information, and system status.

How can I harness data generated by the DASGIP system?

With DASware control all data and events are logged in one central SQL Server database. Further features such as export into Excel, PDF, and other file formats via one mouse click and strong charting capabilities ease plotting and data analysis. To harness data from numerous projects, on the long-run advanced archiving capabilities and data retrieval is required. DASware discover offers comprehensive and user-defined archiving functions and data retrieval for powerful data comparison and analysis. Users can, for example, link the utilized strain or cell line with its media composition, the controller setpoints and feeding profiles as well as with achieved product yields or viable cell densities to select for the best optimized combination and process.

Does DASware control give any alarms in case of critical deviation?

Critical deviation of process parameters such as pH, DO, redox, and temperature are color-coded in the software and saved in the event log. DASware control professional additionally allows notification of supervisory control systems or mobile communication tools via SMS or e-mail.

Can you help adjusting my controller loop parameters in DASware control?

DASGIP controllers are PI controllers, which are configured with default controller parameters adapted to the type of vessel and default experimental requirements. Depending on special customer requirements it might be necessary to modify these parameters. Our service will be happy to help you finding the right settings.

How to calibrate a pH sensor in DASware control?

DASware control software allows for parallel calibration of all sensors used within one system with all data logged in the central database together with set-points, profiles, cascades, process values, user interactions and other events. Good maintenance will prolong the sensors' lifetime whereas high temperatures (i.e. during autoclavation), alkaline solutions (i.e. during alkaline deactivation), repeated etchings and improper maintenance will reduce the electrode's lifetime.

How reliable are exhaust data when working at benchtop scale?

Exhaust oxygen and carbon dioxide concentrations of multiple bioreactor units are continuously monitored with the DASGIP GA exhaust analyzer. Together with the mass flow measurement and the input values of oxygen and carbon dioxide concentrations, automatic calculation of oxygen transfer rate (OTR), carbon dioxide transfer rate (CTR), and respiratory quotient (RQ) is possible, permitting direct conclusions on the metabolic state of a culture. As the DASGIP GA considers humidity, volume, and total flow typical sources for inaccurate OTR and CTR data in small working volumes are eliminated.

Is it possible to automatically control the foam in DASGIP vessels?

All DASGIP vessels can be equipped with foam control components. All you need is a level/foam sensor connected to the DASGIP sensor module (e.g. PH4PO4L) and a feed line for dosing of the antifoam agent. Now foam formation can be detected by the level sensor and antifoam agent is automatically pumped into the vessel until all foam is collapsed. The DASware control software allows any feed line to be used for antifoam or level control. Since medium composition has a strong impact on the electrical conductivity of medium and foam, every conductivity-based level sensor needs to be adjusted to foam and medium conductivity. DASware control supports monitoring conductivity and free adjustment of the conductivity threshold.

What maintenance is required for Eppendorf bioprocess systems?

As all complex technical systems Eppendorf bioprocess equipment should be maintained regularly to keep all parts in good condition. This maintenance avoids cost-intensive down times and contributes to preservation of value. A complete preventive maintenance is recommended once a year. Additional maintenance actions are recommended to be executed by the user prior to every run or in regular cycles (e.g. every month). Our service will be happy to advice.

What do I have to consider when returning equipment for repair?

Equipment returned to Eppendorf for service or any other reason needs to be decontaminated first. Please fill out the Decontamination Form that you will find in the “Service & Support” section of the Eppendorf website and attach it to the package. Equipment which was sent without the completely filled form cannot be handled. This form must also be completed before any on-site service, whether covered under warranty or not, can commence.

What does your warranty cover?

Eppendorf issues a warranty of one year from the day of delivery on its products in accordance with our terms and conditions. Excluded are consumables such as cables, tubing, glassware, and sensors as well as used material.

Does Eppendorf offer bioreactor training?

We highly recommend a training at the customer’s site for all new customers. Besides this initial training, Eppendorf also offers individual trainings adapted to the user’s requirements like training of new employees or advanced training/recapitulation for employees already having experience with DASGIP or DASbox systems. All trainings are performed at the customer’s site using the customer’s equipment to have the training focused on the customer’s demands. The structure and methods of the training can be chosen to the customer’s requirements from general overview to detailed sessions on specific products or issues. Training in small groups is as possible as personal guidance.

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DASGIP^® Parallel Bioreactor System

Produktinformationen

Das DASGIP Parallel Bioreactor System ist ein Bioreaktorsystem für die Forschung und Prozessentwicklung mit Arbeitsvolumen von 200 mL bis 1,8 L. Es kann bis zu 16 Glasbioreaktoren oder BioBLU^® Single-Use Bioreactors parallel betreiben und ist geeignet für mikrobielle Fermentation und Zellkultivierung, einschließlich der Kultivierung von Stammzellen. Der modulare Aufbau ermöglicht es Anwendern, die für ihre Anwendung am besten geeignete Konfiguration zu wählen.

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Eigenschaften

Das DASGIP Parallel Bioreactor System ermöglicht eine hocheffiziente Prozessentwicklung durch präzise Kontrolle über kritische Prozessparameter, schnelle Vergleiche zahlreicher Versuchsbedingungen und die optimale Nutzung aller generierten Daten.
• Paralleler Betrieb von bis zu 16 Bioreaktoren spart Zeit und Platz und verbessert die Reproduzierbarkeit.
• Einfach umrüstbar von Einweg- zu wiederverwendbaren Bioreaktoren und umgekehrt.
• Die DASware^® Software Suite ermöglicht die präzise Überwachung und Steuerung kritischer Prozessparameter sowie die Implementierung maßgeschneiderter Feedback-Loops, Feeding-Strategien und anderer Funktionen.
• Die nahtlose Kombination mit dem Bioprocess Autosampler ermöglicht eine automatisierte Probenahme rund um die Uhr, um vollständige Datensätze zu erhalten.
• Kann zur Fernüberwachung von Prozessen und zur einfachen Fernanalyse aller Datensätze für informierte Entscheidungen mit der BioNsight^® cloud-Software verbunden werden.

Betreiben Sie mehrere Bioreaktoren parallel

• Das DASGIP Parallel Bioreactor System ist als Vierfach-System ausgelegt, das auf bis zu 16 parallel betriebene Bioreaktoren erweitert werden kann.
• Sollwerte, Regelstrategien und Inokulationszeit jedes Bioreaktors können individuell über eine Softwareinstallation gesteuert werden. Auf diese Weise können mehrere Versuchsbedingungen parallel getestet werden.

Automatisieren Sie die Probenahme in Bioprozessen

• Das Bioreaktorsystem kann nahtlos mit dem Bioprocess Autosampler kombiniert werden, der in kurzen und regelmäßigen Abständen rund um die Uhr Proben aus mehreren Bioreaktoren entnimmt und für die spätere Analyse temperiert lagert.
• Der Bioprocess Autosampler kann mit neuen Bioreaktor-Steuerungssystemen installiert oder bei bestehenden Systemen nachgerüstet werden.

Geeignet für Zellkultivierung und mikrobielle Fermentation

• Das DASGIP Parallel Bioreactor System ist für verschiedenste Zelltypen geeignet, einschließlich Bakterien, Hefen, Insektenzellen, differenzierter Säugetierzellen und Stammzellen.
• Für die Anforderungen an den Gasfluss in mikrobiellen Anwendungen und Zellkulturanwendungen wurden zwei verschiedene Varianten entwickelt.
• Das DASGIP Parallel Bioreactor System ist kompatibel mit Bioreaktoren für mikrobielle Kulturen und Zellkulturen.

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Spezifikationen	DASGIP^® Parallel Bioreactor System	DASGIP^® Parallel Bioreactor System

Anwendung	Zellkultur	Mikrobiologie
Anzahl paralleler Einheiten	bis zu 16	bis zu 16
Software	DASware control, andere DASware optional erhältlich	DASware control, andere DASware optional erhältlich
Benutzeroberfläche	Prozessrechner mit Monitor	Prozessrechner mit Monitor
Typische Leistungsaufnahme (4-fach-System ohne Prozessrechner)	480 W (bei 230 V)/ 432 W (bei 115 V) (595 W/552 W ohne DASGIP Bioblock)	541 W (bei 230 V)/ 467 W (bei 115 V) (639 W/584 W ohne DASGIP Bioblock)
Abmessungen (B × T × H, 4-fach-System ohne Prozessrechner)	140 x 70 x 53 cm (55 x 28 x 21 in)	140 x 70 x 53 cm (55 x 28 x 21 in)
Typisches Gewicht	78 kg (60 kg ohne DASGIP Bioblock)	96 kg (78 kg ohne DASGIP Bioblock)
Bakterien/Hefen/Pilze	ja	ja
Säuger-/tierische Zellen	ja	ja
Insektenzellen	ja	ja
Austauschbare Gefäße	ja	ja
Validierbar	nein	nein
Stammzellen	ja	ja

Bioreaktoren
Gefäße	Glas-/Einweggefäße	Glas-/Einweggefäße
Sterilisation	Autoklavierbar/ vorsterilisiert	Autoklavierbar/ vorsterilisiert
Gesamtvolumen	1,5 L bis 2,3 L	1,3 L bis 2,1 L

Rührer
Antrieb	Direkter/magnetischer Überkopfantrieb	Direkter/magnetischer Überkopfantrieb
Drehzahlbereiche	30 – 1.250 rpm (Standard)/ 100 – 1.600 rpm (optional)	100 – 1.600 rpm (Standard)/ 30 – 1.250 rpm (optional)
Rührer	Schrägblattrührer	Rushton-Typ-Rührer

Begasung
Gasversorgung	TMFC; Sparger und/oder Kopfraumbegasung	TMFC/Rotameter; Sparger
Standardbegasungsraten	0,1 – 50 sL/h, 0,1 – 40 sL/h CO₂ (DASGIP MX4/4, andere Module erhältlich)	0,5 – 250 sL/h, 0,5 – 150 sL/h CO₂ (DASGIP MX4/4H, andere Module erhältlich)
Standard-Gasmischung	Luft, N₂, O₂ und/oder CO₂	Luft, N₂, O₂ und/oder CO₂

Feeding
Dosierleitungen pro Gefäß	Bis zu 8	Bis zu 8
Standarddosierraten (abhängig vom Gefäßdurchmesser)	0,3 – 9,5 mL/h bis 13 – 420 mL/h (DASGIP MP8) 10 – 70 mL/h bis 0,4 – 5 L/h (DASGIP MP4)	0,3 – 9,5 mL/h bis 13 – 420 mL/h (DASGIP MP8) 10 – 70 mL/h bis 0,4 – 5 L/h (DASGIP MP4)

Überwachung und Steuerung
Temperaturregelung	Heizung und Kühlung im DASGIP Bioblock integriert (zusätzliche Kühlfinger optional)	Heizung und Kühlung im DASGIP Bioblock integriert (zusätzliche Kühlfinger optional)
Standardtemperaturbereich (bei 25 °C Umgebungstemp.)	5 K über Kühlmitteltemperatur –99 °C (DASGIP Bioblock)¹⁾	5 K über Kühlmitteltemperatur –99 °C (DASGIP Bioblock)¹⁾
pH-Regelung	−	Säure und/oder Base und andere Set-ups
DO-Regelung	Kaskade (O₂-Konzentration, Begasungsrate) und andere Set-ups	Kaskade (Rührgeschwindigkeit, O₂-Konzentration optional, Begasungsrate optional) und andere Set-ups
ORP-Messung (Redox)	-	Optional
Level/Schaum	Optional	Optional
OD-Messung	Optional (DASGIP OD4)	Optional (DASGIP OD4)
Abgaskondensation	wassergekühlt oder flüssigkeitsfrei (Peltier mit DASGIP EGC4)	wassergekühlt oder flüssigkeitsfrei (Peltier mit DASGIP EGC4)
Abgasanalyse	Optional (DASGIP GA4)	Optional (DASGIP GA4)
1)Es können anwendungsspezifische Betriebsbedingungen gelten.

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Upstream bioprocess solutions for research through production

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DASGIP® Parallel Bioreactor System