Going for the right impeller can greatly increase yields of picky cell lines and even stem cells. With a wide variety of impeller designs how can we determine which one is best?
All stirred-tank bioreactors are designed to homogenously mix cells, nutrients, and gases. The impeller evenly distributes oxygen and substrates to the cells for healthy growth. It keeps them from settling to the bottom of the vessel and helps maintain a stable, even temperature. Depending on the impeller you choose, mixing will be achieved by radial or axial flow – or a combination of both.
How blade orientation affects mixing