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GMP info

Regarding suitability of Eppendorf bioprocess equipment in GMP-regulated applications, please reach out to your Eppendorf sales representative.

Monoclonal Antibody Production in Bioreactors

Monoclonal antibody production using scalable bioprocess systems
At Eppendorf, our aim is to empower your upstream bioprocessing to produce monoclonal antibodies and other therapeutic proteins in bioreactors. We provide tools that help you accelerate process development by working in parallel, increasing turn-around, and leveraging the full potential of bioprocess data. We help scaling up your process from R&D to clinical and commercial manufacturing while maintaining quality and yield. We pay attention to your specific challenges, and we work together with you to solve them. So come and talk to us, we are all ears.
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We help you leverage bioprocess intelligence

Develop more reliable, more productive processes faster

We offer orchestrated bioreactor, software, and service solutions that let you combine experimental efficiency with smart use of data. Discover our bioprocess solutions that support you to increase speed through parallel processing, automation, and efficient data analysis. Find out how our software solutions can leverage the power of artificial intelligence to translate data into strategies to increase product yield and quality.

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Discover our bioprocess development solutions

Reduce risks and save time with single-use technology

Our single-use technology helps you increase throughput, flexibility, and safety in bioprocessing. BioBLU® Single-Use Bioreactors eliminate the need for labor-intensive cleaning procedures, cleaning validation, and hold time validation. With built-in measures to minimize the risk of contamination, they enable you to act quickly while significantly reducing the risk of costly and time-consuming batch failures in both research and manufacturing environments.

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Discover BioBLU Single-Use Bioreactors

Seamlessly transition from R&D to manufacturing

Maintain consistency and quality as you scale-up. Our scalable bioprocess solutions help you seamlessly translate your R&D successes into manufacturing. Our solution package of bioprocess controllers, bioreactors, bioprocess SCADA software, and services support the compliance of your bioprocesses with GMP requirements in clinical and commercial manufacturing.

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Discover our clinical and commercial manufacturing solutions

Advance the use of your bioprocess data and simplify collaboration

Our software solutions help you advance the use of your bioprocess data, starting from remote process monitoring to process control and automation, to collaboration and contextualization of data across instruments, runs and sites. Find out more about how our software solutions and bioprocess systems work in harmony to provide a complete
upstream bioprocessing solution.

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Discover our bioprocess software

Get to know the Eppendorf bioprocess products

The Eppendorf bioprocess portfolio offers scalable bioprocess systems, single-use bioreactors, software solutions, and services to efficiently develop processes and move them from R&D to manufacturing.
Discover our bioprocess products

Let’s grow beyond. Your process, from development to manufacturing

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Bioprocess development

Find out how we can help you streamline bioprocess development.
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Bioprocessing scale-up

Get insights into bioprocessing scale-up and how we can support you.
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Bioprocess operation modes

Learn about batch, fed-batch, and continuous culture and discover our perfusion solutions.
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Process analytical technology

Find out how we can help you use process analytics to develop control strategies tailored to your needs.
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mAB solutions for biopharma

From producing target antigens up to cell line development, Eppendorf’s solutions provide excellence at every step!

Get inspired by these resources on mAB production in bioreactors

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Ebook: Bioprocessing Methods for mAB Generation

Originally, hybridoma cells were generated for mAB production. Today, Chinese Hamster Ovary cells are often used as an expression system. Antibody production in bacteria or yeast offers greater speed, however there are challenges associated with glycosylation. Find out more in our ebook!
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Webinar: Optimize Your Plasmid Yields

Plasmid production comprises different workflow steps, including vector and strain selection, inoculum preparation in shake flasks, plasmid production in bioreactors, harvesting, and purification. Get expert advice for the optimization of plasmid production in shake flasks and bioreactors.
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Ebook: Increasing the Reproducibility of Cell Culture Bioprocesses

Cells, culture medium, and a bioprocess control system are required components of each upstream bioprocess but each of them can be a source of variability and affect cell growth, viability, product formation, and product quality. Get to know more about factors which can contribute to inconsistent results.

How our customers use our products

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UGA Biopharma: Scaling-up from small to bench scale

Scaling the process up to larger volumes is a critical milestone in the development of monoclonal antibodies. Read, how scientists at UGA Biopharma scaled-up a biosimilar production process from small to bench scale using the kLa value as a scale-up criterium.

Download application note
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KTH Royal Institute of Technology: Small-scale perfusion

Small scale perfusion systems are desired to save resources and reduce costs during process development, however, they are not very well established. Read how researchers at the KTH Royal Institute of Technology in Sweden established ATF perfusion cultivation of an antibody-producing CHO cell line at a working volume of only 230 mL.

Download application note
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GenMab A/S: Antibody development

Scientists from GenMab A/S, an international biotechnology company specializing in the development of antibody-based therapeutics, were among the first SciVario® twin users. Get to know, which system’s features they find helpful to tackle challenges in antibody development.

Watch video
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Alvotech®: Bioprocess development for biosimilar production

Bioprocess development for biosimilar production: Scientists from Alvotech® share insights on which process parameters are key to ensure consistent product quality and how automation can make the scientists’ lives easier.

Read interview
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Roche Pharma Technical Development: Improve pH sensor recalibration

The pH of the culture medium strongly influences process performance. Read, how scientists at Roche Pharma Technical Development used exhaust CO2 readings for improved pH sensor recalibration to match the starting pH of carbonate-buffered systems – for increased process reproducibility cross plants, sites, and scales.

Download application note
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APC: Raman analyzer integration

Scientists at APC, Ltd integrated a Raman analyzer and a model predictive controller algorithm with a DASGIP® Parallel Bioreactor System. Read, how this allowed them increasing the cell density of their CHO cell bioprocess by automizing glucose control.

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