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Nucleic acid purification

Nucleic acid purification (NAP) is fundamental for isolating high‑quality DNA or RNA and supports reliable results in downstream applications.

About the nucleic acid purification workflow

Nucleic Acid Purification (NAP) is the process of preparing high-quality DNA or RNA samples for downstream analysis. Primary samples may range from cell cultures over blood to bacterial and plant materials. The two major routes to obtain pure nucleic acids are filtration-based systems, e.g. spin columns or filter plates, as well as magnetic bead-based processes.

Even though being routine workflows in most laboratories, doing NAP takes hours of manual labour, particularly when working with many samples in parallel.

Challenges in nucleic acid purification

Labour-intensive processes
Risk of cross-contamination, sample mix-up, and loss of sample
Handling difficult samples and challenging reagents
Need for high reproducibility and traceability

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How our automated liquid handlers help

epMotion streamlines NAP across filtration and magnetic bead workflows, from DNA/RNA extraction to clean‑ups. Pre‑validated methods cover leading kit vendors and diverse chemistries to streamline entry into automation with typical batch sizes up to 96 samples. Flexible software allows for customized protocol optimization, and built‑in sample tracking and documentation deliver full traceability. The open platform supports varied labware and challenging sample types. To automate further steps, downstream PCR or NGS library prep workflows can be executed in the same instrument.

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Why our expertise matters

We know downstream success depends on the quality of your purified nucleic acids. Our application specialists help automate and optimize extraction and cleanups across filtration and magnetic bead chemistries. With Eppendorf, you gain a partner who knows the critical points of NAP, from lysis and binding to wash stringency and elution recovery

Explore a wide variety of ready-to-use protocols for NAP and more. Discover how easy it is to own your solution.

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