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BioFlo® 320 for commercial manufacturing
BioFlo 320 with BioBLU 50c and scale

O BioFlo 320 é compatível com dornas descartáveis BioBLU 250 mL - 40 L.
Informações do produto
The BioFlo 320 is a universal bench-scale bioreactor system for both process development and clinical and commercial manufacturing. Powerful technology for precise process monitoring and control, a large working volume range, and software features that save time and reduce risks make it a reliable partner for developing robust processes and scaling them up from R&D to manufacturing. It is suitable for cell culture as well as fermentation application.Há material adicional disponível para download no final desta página
Produtos (2)
Acessórios (14)
2 Produtos
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Catálogo n.º
M137900000
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Informações do produto
Aplicações
Recursos
Informações do produto
The BioFlo 320 seamlessly connects R&D to clinical and commercial manufacturing
The BioFlo 320 is compatible with a wide selection of bioreactors, providing working volumes from 400 mL to 40 L on a single platform. In combination with the BioFlo 720 bioreactor control system, the BioFlo platform supports one of the widest range of single-use solutions, allowing the scale-up of your process to up to 500 L.
• Validation Guide available to support controller qualification for manufacturing applications.
• In combination with BioBLU HNQ Single-Use Bioreactors, DASware control plus SCADA software, and service offerings for qualification and calibration, the BioFlo 320 provides a unified solution to support compliance with GMP requirements.
• Integrated Scale Up Assist software feature simplifies the calculation of important process parameters necessary to scale up and down.
• Emerson® DeltaV integration with the BioFlo 320 simplifies tech-transfer, scale-up, and recipe sharing.
The BioFlo 320 is highly configurable to meet your application needs
Advanced technical features make the BioFlo 320 a powerful tool for R&D as well as manufacturing. A high level of application flexibility is made possible by features like universal connections for analog and digital sensors, up to six integrated pumps, a highly configurable gas flow control, and compatibility with a wide range of glass and single-use bioreactors.
• Suitable for the cultivation of human and animal cells, including stem cells, as well as microbial fermentation.
• Supports batch, fed-batch, continuous, and perfusion mode.
• Suitable for many applications, including the production of cells, secreted proteins, viral vectors, plasmids, and small molecules.
Eppendorf Bioprocess Products – application in GMP regulated environment
Download document to find out which features you can expect at minimum from Eppendorf products that are deemed suitable or compatible for GMP.
The BioFlo 320 is compatible with a wide selection of bioreactors, providing working volumes from 400 mL to 40 L on a single platform. In combination with the BioFlo 720 bioreactor control system, the BioFlo platform supports one of the widest range of single-use solutions, allowing the scale-up of your process to up to 500 L.
• Validation Guide available to support controller qualification for manufacturing applications.
• In combination with BioBLU HNQ Single-Use Bioreactors, DASware control plus SCADA software, and service offerings for qualification and calibration, the BioFlo 320 provides a unified solution to support compliance with GMP requirements.
• Integrated Scale Up Assist software feature simplifies the calculation of important process parameters necessary to scale up and down.
• Emerson® DeltaV integration with the BioFlo 320 simplifies tech-transfer, scale-up, and recipe sharing.
The BioFlo 320 is highly configurable to meet your application needs
Advanced technical features make the BioFlo 320 a powerful tool for R&D as well as manufacturing. A high level of application flexibility is made possible by features like universal connections for analog and digital sensors, up to six integrated pumps, a highly configurable gas flow control, and compatibility with a wide range of glass and single-use bioreactors.
• Suitable for the cultivation of human and animal cells, including stem cells, as well as microbial fermentation.
• Supports batch, fed-batch, continuous, and perfusion mode.
• Suitable for many applications, including the production of cells, secreted proteins, viral vectors, plasmids, and small molecules.
Eppendorf Bioprocess Products – application in GMP regulated environment
Download document to find out which features you can expect at minimum from Eppendorf products that are deemed suitable or compatible for GMP.


Sensores inteligentes
• Plataforma Integrada de Gerenciamento Inteligente de Sensores (ISM) Mettler Toledo
• Conexões universais para até quatro sensores analógicos ou digitais (ISM)
• pH: analógico ou digital (ISM)
• OD: analógico ou digital (ISM)
• OD óptico: digital (ISM)
• Redox: analógico ou digital (ISM)
• CO2: digital (ISM)
• Diagnóstico do sensor em tempo real antecipa a falha do sensor




Conectividade com o DASware control plus
Para ser utilizado no fabricação clínica e comercial, o BioFlo 320 pode ser ligado ao poderoso software DASware control plus SCADA.
• Compatível com 21 CFR Parte 11 e EudraLex Volume 4 Anexo 11
• Autenticação do usuário e controlo de acesso
• Registros e assinaturas eletrônicos
A utilização do conjunto de software DASware oferece funcionalidades avançadas para o controle de processos, como a integração de sensores externos e a criação de scripts de circuitos de feedback
• Controle de até oito unidades a partir de uma única interface de usuário.
• Algoritmos de mistura automática de gases para um controle simplificado (4 gases, 3 gases); enriquecimentode O2, enriquecimento de N2
• Função de cascata de dez pontos para estratégias de controle sofisticadas
• As funções de alarme informam automaticamente sobre o estado do processo através da visão geral do histórico de alarmes no controlador e da opção de enviar e-mails quando ocorre um alarme.
• A tela de diagnóstico fornece informações sobre o estado do hardware e a manutenção futura.
• Calibração automática: a calibração automática de todos os sensores de OD ligados de uma só vez reduz significativamente o tempo de preparação e assegura a consistência.




Obter informações sem problemas e promover a colaboração
Todos os dados coletados pelo DASware control podem ser visualizados sem problemas no software BioNsight cloud.
Permite ao usuário acompanhar e monitorar processos em execução em tempo real e analisar processos remotamente.
• Monitorar todos os processos em execução em tempo real.
• Comparar com a execução do golden batch.
• Compartilhar dados entre laboratórios, locais ou mesmo parceiros de colaboração.
• Aproveitar a tecnologia de modelação híbrida para prever atributos de qualidade críticos mais rapidamente e reduzir significativamente o número de experimentos.




Área de ocupação reduzida
Desde laboratórios de P&D a instalações de produção em escala piloto, o espaço é um fator importante ao escolher o equipamento certo. O BioFlo 320 oferece flexibilidade, melhor controle e máxima funcionalidade enquanto ocupa apenas uma fração do valioso espaço de laboratório ocupado por sistemas semelhantes. Isto significa maior eficiência e produtividade a um custo operacional mais baixo para o seu laboratório.


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Aplicações
- Universal bench-scale controller for cell culture and fermentation applications in R&D and clinical and commercial manufacturing
- Fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
- Cultivation of mammalian, insect, and human cell lines
- Cultivation of stem cells
- Specialized packed-bed impeller for the cultivation of anchorage and non-anchorage dependent cells, for example for vaccine process development
- Cell culture on microcarriers using specialized cell-lift impeller
- Suitable for batch, fed-batch, and continuous/perfusion processes
- Validation Guide available to support controller qualification for manufacturing applications1)
Recursos
- Universal control for both microbial and cell culture applications
- Controls up to eight systems from a single user interface
- Compatible with BioBLU HNQ Single-Use Bioreactors
- Up to six integrated pumps capable of operating in variable-speed mode
- Integrated Mettler Toledo® ISM® platform
- Built-in optical pH sensing technology for use with the BioBLU HNQ Single-Use Bioreactors
- Field-upgradable TMFC drawers for sparge and overlay gas
- Eight independently controlled process gas supplies
- Enhanced software package with new cascade and time profile features
- DeltaV compatibility available through DeltaV Discovery and DeltaV ProPlus PAS
- Validation Guide available to support controller qualification for manufacturing applications.
- Compatible with 21 CFR Part 11 and EudraLex Volume 4 Annex 11 compatible DASware control plus SCADA software
Downloads: BioFlo® 320 for commercial manufacturing
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