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Monoclonal Antibody Production

Monoclonal antibody production using scalable bioprocess systems
Monoclonal antibody-based immunotherapy is a dominant and growing industry producing a promising class of therapeutics such as targeted anticancer drugs. In order to stay competitive, it’s essential that production can be made more efficient and cost-effective whilst still improving upon quality and concentration. Here you can find out how Eppendorf can help you to optimize your bioprocess for monoclonal antibody (mAb) production.
Monoclonal antibodies are genetically engineered molecules that are designed to act as substitute antibodies and restore, improve, alter, or mimic the immune system's defense against undesirable cells, such as cancer cells. Originally, for monoclonal antibody production mAb-producing cells (hybridomas) were generated by fusing immortal myeloma cells with antibody-producing B cells. Today, Chinese Hamster Ovary (CHO) cells are often used as an expression system. Antibody production in bacteria or yeast offers greater speed, however there are challenges associated with glycosylation. Find out more about antibody production in our infographic.

mAB discovery workflow

Antibody development is not without its challenges. Research teams are under increasing pressure to produce specific, high-quality therapeutic treatments within ever-tighter time and budget restrictions. As such, it is essential to optimize each step of the monoclonal antibody production process, from transfection, to clone selection, to process control and scale-up. From choosing candidate cell lines to scale-up, Eppendorf can help you to maintain a competitive edge by providing the tools, expertise, and knowledge needed to improve and regulate antibody yield and quality.

mAB solutions for biopharma

Expert knowledge: Optimize your bioprocess

Accelerate process development

Learn how the right equipment can accelerate your antibody process development through optimized, real-time parameter control, the ability to set up parallel and scalable reactions, and improved efficiency. With lower development costs and a shorter time for the product to reach the market, your business can stay competitive in an increasingly demanding market.

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Improve reproducibility and yield

Antibody production relies upon the interplay of several bioprocess parameters to influence yield and quality. Bioprocess optimization can help to improve reproducibility, reduce batch-to-batch variation, and increase yields and product quality, helping to save time and money in antibody production. This is especially important when seeking to scale up or perform a process validation. Here, we will consider the factors that can contribute to inconsistent results and offer strategies to increase the reproducibility and productivity of cell culture bioprocesses for the production of antibodies.

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Choose the right bioreactor system for monoclonal antibody production

Learn more about the Eppendorf solutions for upstream bioprocessing.

Parallel, small-scale bioprocess systems‌

Parallel small-scale bioreactor systems like the DASbox® Mini Bioreactor System support customers in implementing QbD principles in their development phase. These high-throughput bioreactor systems are designed for parallel cultivations, making them ideal for experimental design, parallel comparison studies and downscaling experiments.

Single-use bioreactors‌

From small scale to pilot production scale‌

Software‌

Eppendorf Latin America

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