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- Wszystkie wirówki
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- Materiały zużywalne do wirówek wysokoobrotowych i ultrawirówek
- Probówki wirówkowe
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- Zarządzanie próbkami i informacjami
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- Wszystkie pipety, dozowniki oraz automatyczne urządzenia do pracy z cieczami
- Pipety mechaniczne
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- Końcówki do pipet
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- Systemy do pracy z cieczami i serwisowanie pipet
Impact and Consequence
Odkrywaj Life Science
- Nature
- Research
- Zrównoważony rozwój
- Off the Bench
- Odkrywanie życia
Environmental factors such as noise, fine particulates in the air and stress make up our exposome. Its study promises enormous potential for medicine.
The same is true for smoking and psychosocial factors such as fear, loneliness or stress. This poses a number of methodological challenges to those investigating the exposome. Double-blind laboratory studies, often considered the gold standard, are neither possible nor meaningful; rather, longitudinal epidemiological studies are needed when it comes to observing the effects of environmental factors. Using a variety of different data sources, researchers are attempting to capture the individual stressors to which study participants are exposed over an extended period of time. To this end, they utilize satellite data on air quality, noise and light, as well as sensors and smart watches worn by participants.
The digital fingerprint of the environment as detected in the body
The stressors a person experiences through environmental influences are correlated with biological changes inside the body. These can be measured via “omics” analyses. “A digital fingerprint of the environment is created in the body, a kind of ‘biochemical diary’ of our lives”, says Professor Münzel. These analyses allow deductions regarding metabolic processes which are subject to change based on environmental factors.
Exposome analyses could potentially initiate a revolution in prevention and diagnostics, says Thomas Münzel: “‘Molecular signatures’ enable the detection of environmental stressors in the blood before diseases will become apparent.” Even personalized prevention will be possible: those who react strongly to noise or dust particulates may be protected more effectively.
The cardiologist also envisions great potential for new therapeutic approaches. Environmental factors exert their influence via biochemical signaling pathways including oxidative stress and disruptions of the circadian rhythm – the body’s internal clock. “The knowledge gained from exposome research opens up novel therapeutic options for diseases such as hypertension, atherosclerosis and cardiac insufficiency”, says Münzel.
A risky lifestyle
For the scientist and many of his colleagues, this still very young field of research carries with it political responsibility: environmental stressors are to be included in guidelines and health policy as modifiable risk factors. He says: “The safeguarding of health does not begin in the clinic but rather with city planning and everyday life.” Many of the exposome risk factors are directly connected to our modern way of life: traffic, industrial manufacturing, food production and much more. Changing these systems is beyond the capabilities of the individual.
Yet, everyone can improve their own personal exposome, says Thomas Münzel. His advice: do not smoke, reduce noise, stay away from the cell phone while in bed, get some exercise outside in nature, pay attention to a healthy diet and, if possible, choose organic. Air out indoor spaces regularly and stay in touch with friends and family. None of this is new, but over a lifetime, these influences add up. Many diseases can be prevented before they emerge – with the added benefit of the immediate joy of taking the dog for a walk or running through the forest.
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