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BioFlo® 320 for commercial manufacturing
BioFlo 320 with BioBLU 50c and scale

BioFlo 320은 250 mL - 40 L BioBLU 일회용 Vessel과 호환됩니다.
제품 정보
The BioFlo 320 is a universal bench-scale bioreactor system for both process development and clinical and commercial manufacturing. Powerful technology for precise process monitoring and control, a large working volume range, and software features that save time and reduce risks make it a reliable partner for developing robust processes and scaling them up from R&D to manufacturing. It is suitable for cell culture as well as fermentation application.이 페이지 하단에서 추가 다운로드 자료를찾을 수 있습니다.
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제품 정보
애플리케이션
특징
제품 정보
The BioFlo 320 seamlessly connects R&D to clinical and commercial manufacturing
The BioFlo 320 is compatible with a wide selection of bioreactors, providing working volumes from 400 mL to 40 L on a single platform. In combination with the BioFlo 720 bioreactor control system, the BioFlo platform supports one of the widest range of single-use solutions, allowing the scale-up of your process to up to 500 L.
• Validation Guide available to support controller qualification for manufacturing applications.
• In combination with BioBLU HNQ Single-Use Bioreactors, DASware control plus SCADA software, and service offerings for qualification and calibration, the BioFlo 320 provides a unified solution to support compliance with GMP requirements.
• Integrated Scale Up Assist software feature simplifies the calculation of important process parameters necessary to scale up and down.
• Emerson® DeltaV integration with the BioFlo 320 simplifies tech-transfer, scale-up, and recipe sharing.
The BioFlo 320 is highly configurable to meet your application needs
Advanced technical features make the BioFlo 320 a powerful tool for R&D as well as manufacturing. A high level of application flexibility is made possible by features like universal connections for analog and digital sensors, up to six integrated pumps, a highly configurable gas flow control, and compatibility with a wide range of glass and single-use bioreactors.
• Suitable for the cultivation of human and animal cells, including stem cells, as well as microbial fermentation.
• Supports batch, fed-batch, continuous, and perfusion mode.
• Suitable for many applications, including the production of cells, secreted proteins, viral vectors, plasmids, and small molecules.
Eppendorf Bioprocess Products – application in GMP regulated environment
Download document to find out which features you can expect at minimum from Eppendorf products that are deemed suitable or compatible for GMP.
The BioFlo 320 is compatible with a wide selection of bioreactors, providing working volumes from 400 mL to 40 L on a single platform. In combination with the BioFlo 720 bioreactor control system, the BioFlo platform supports one of the widest range of single-use solutions, allowing the scale-up of your process to up to 500 L.
• Validation Guide available to support controller qualification for manufacturing applications.
• In combination with BioBLU HNQ Single-Use Bioreactors, DASware control plus SCADA software, and service offerings for qualification and calibration, the BioFlo 320 provides a unified solution to support compliance with GMP requirements.
• Integrated Scale Up Assist software feature simplifies the calculation of important process parameters necessary to scale up and down.
• Emerson® DeltaV integration with the BioFlo 320 simplifies tech-transfer, scale-up, and recipe sharing.
The BioFlo 320 is highly configurable to meet your application needs
Advanced technical features make the BioFlo 320 a powerful tool for R&D as well as manufacturing. A high level of application flexibility is made possible by features like universal connections for analog and digital sensors, up to six integrated pumps, a highly configurable gas flow control, and compatibility with a wide range of glass and single-use bioreactors.
• Suitable for the cultivation of human and animal cells, including stem cells, as well as microbial fermentation.
• Supports batch, fed-batch, continuous, and perfusion mode.
• Suitable for many applications, including the production of cells, secreted proteins, viral vectors, plasmids, and small molecules.
Eppendorf Bioprocess Products – application in GMP regulated environment
Download document to find out which features you can expect at minimum from Eppendorf products that are deemed suitable or compatible for GMP.


지능형 센서
• 통합 Mettler Toledo Intelligent Sensor Management(ISM) 플랫폼
• 최대 4개의 아날로그 또는 디지털(ISM) 센서의 범용 연결
• pH: 아날로그 또는 디지털(ISM)
• DO: 아날로그 또는 디지털(ISM)
• 광학 DO: 디지털(ISM)
• Redox: 아날로그 또는 디지털(ISM)
• CO2: 디지털(ISM)
• 실시간 센서 진단을 통한 센서 고장 예측




DASware control plus 연결
임상 및 산업 생산 환경에서 사용하기 위해 BioFlo 320를 강력한 DASware control plus SCADA 소프트웨어에 연결할 수 있습니다.
• 21 CFR Part 11 및 EudraLex Volume 4 Annex 11 준수
• 사용자 인증 및 접근 제어
• 전자 기록 및 전자 서명
DASware 소프트웨어 제품군을 사용하면 외부 센서 통합과 피드백 루프 스크립팅 등 프로세스 제어를 위한 고급 기능을 활용할 수 있습니다.
첨단 소프트웨어 솔루션을 통한 시간 절약 및 위험 최소화
• 단일 사용자 인터페이스에서 최대 8개의 장치를 제어할 수 있습니다.
• 효율적인 제어를 위한 자동 기체 혼합 알고리즘(4기체, 3기체), O2 농축, N2 농축
• 최신 제어 전략을 위한 10포인트 캐스케이드 기능
• 알람 기능은 컨트롤러의 알람 기록과 알람 발생 시 이메일 전송 옵션을 통해 프로세스 상태를 자동으로 알려줍니다.
• 진단 화면은 하드웨어 상태와 예정된 유지보수에 대한 정보를 제공합니다.
• 자동 검교정 - 연결된 모든 DO 센서를 한 번에 자동 검교정하여 준비 시간을 크게 줄이고 일관성을 보장합니다.




원활한 인사이트 확보와 협업 촉진
DASware control 이 수집한 모든 데이터를 BioNsight cloud 소프트웨어에서 완전하게 시각화할 수 있습니다.
사용자가 실행 중인 프로세스를 실시간으로 추적 및 모니터링하고 원격으로 분석할 수 있습니다.
• 실행 중인 모든 프로세스를 실시간으로 모니터링합니다.
• 골든 배치와 비교합니다.
• 실험실, 현장, 협력 파트너 간에 데이터를 공유합니다.
• 하이브리드 모델링 기술을 활용해 중요 품질 특성을 빠르게 예측하고 실험 횟수를 크게 줄입니다.




작은 설치 공간
R&D 실험실에서 파일럿 스케일 생산 시설에 이르기까지 공간은 장비 선택을 결정하는 중요 요인입니다. BioFlo 320는 다른 시스템에 비해 작은 실험실 공간을 차지하면서 탁월한 유연성, 제어 성능 및 기능성을 제공합니다. 그 결과 실험실 운영 비용을 절약하면서 효율과 생산성을 개선할 수 있습니다.


자세히 보기
간단히 보기
애플리케이션
- Universal bench-scale controller for cell culture and fermentation applications in R&D and clinical and commercial manufacturing
- Fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
- Cultivation of mammalian, insect, and human cell lines
- Cultivation of stem cells
- Specialized packed-bed impeller for the cultivation of anchorage and non-anchorage dependent cells, for example for vaccine process development
- Cell culture on microcarriers using specialized cell-lift impeller
- Suitable for batch, fed-batch, and continuous/perfusion processes
- Validation Guide available to support controller qualification for manufacturing applications1)
특징
- Universal control for both microbial and cell culture applications
- Controls up to eight systems from a single user interface
- Compatible with BioBLU HNQ Single-Use Bioreactors
- Up to six integrated pumps capable of operating in variable-speed mode
- Integrated Mettler Toledo® ISM® platform
- Built-in optical pH sensing technology for use with the BioBLU HNQ Single-Use Bioreactors
- Field-upgradable TMFC drawers for sparge and overlay gas
- Eight independently controlled process gas supplies
- Enhanced software package with new cascade and time profile features
- DeltaV compatibility available through DeltaV Discovery and DeltaV ProPlus PAS
- Validation Guide available to support controller qualification for manufacturing applications.
- Compatible with 21 CFR Part 11 and EudraLex Volume 4 Annex 11 compatible DASware control plus SCADA software
다운로드: BioFlo® 320 for commercial manufacturing
또한 고려할 수 있습니다.