Monoclonal Antibody Production

Eppendorf offers a scalable portfolio of single-use bioreactors, for seamless process scale-up from R&D labs to pilot production facilities.

• The BioBLU® c Single-Use Bioreactors cover a working volume range of 100 mL to 40 L. These are rigid wall, stirred-tank bioreactors, which are compatible with various Eppendorf bioreactor control systems, including the DASbox® Mini Bioreactor System , the SciVario® twin , and the BioFlo® 320 bioreactor control system .
• For scale-up to larger volumes Eppendorf offers the BioFlo® 720 bioreactor control system , which is compatible with Thermo Scientific^™ HyPerforma^™ 5:1 single-use bioreactors with a working volume up to 2000 L.
  

Bioprocess scale-up from small development scale to pilot scale is a fundamental part of process development in the biopharmaceutical industry. Eppendorf provides upstream bioprocess solutions that make it simple to scale up your antibody production. Small and bench-scale bioreactors, including the DASbox® Mini Bioreactor System and the BioFlo® 320 bioreactor control system are compatible with glass and single-use bioreactors and can be used with a range of volumes from 0.25 - 40 L. For larger processes, the BioFlo® 720 can handle much larger working volumes of up to 2000 L.The BioFlo^® 320 and 720 bioreactor control systems have an integrated Scale Up Assist software to simplify the workflow and calculations necessary for scale up.

Eppendorf bioprocess software including DASware® control and BioCommand® can be implemented into bioreactor control systems for advanced process monitoring and control in monoclonal antibody production. They provide real-time insights to help improve product quality, including process automation features, intelligent recipe management, and integrated report generating capabilities. Eppendorf bioprocess software facilitates the integration of process analytical technology (PAT) .