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- Bacteria Versus Body Cells: A 1:1 Tie
- Behind the Crime Scene: How Biological Traces Can Help to Convict Offenders
- Every 3 Seconds Someone in the World Is Affected by Alzheimer's
- HIV – It’s Still Not Under Control…
- How Many Will Be Convicted This Time?
- Malaria – the Battle is Not Lost
- Physicians on Standby: The Annual Flu Season Can Be Serious
- At the Forefront in Fighting Cancer
- Molecular Motors: Think Small and yet Smaller Again…
- Liquid Biopsy: Novel Methods May Ease Cancer Detection and Therapy
- They Are Invisible, Sneaky and Disgusting – But Today It’s Their Special Day!
- How Many Cells Are in Your Body? Probably More Than You Think!
- What You Need to Know about Antibiotic Resistance – Findings, Facts and Good Intentions
- Why Do Old Men Have Big Ears?
- The Condemned Live Longer: A Potential Paradigm Shift in Genetics
- From Research to Commerce
- Chronobiology – How the Cold Seasons Influence Our Biorhythms
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- Eyes on Cancer Therapy
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BioFlo® 320 for commercial manufacturing
BioFlo 320 with BioBLU 50c and scale

BioFlo 320は250 mL - 40 L BioBLU 使い捨て容器と互換です
製品情報
The BioFlo 320 is a universal bench-scale bioreactor system for both process development and clinical and commercial manufacturing. Powerful technology for precise process monitoring and control, a large working volume range, and software features that save time and reduce risks make it a reliable partner for developing robust processes and scaling them up from R&D to manufacturing. It is suitable for cell culture as well as fermentation application.追加でダウンロードできる材料がありますこのページの最後に
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製品情報
アプリケーション
特徴
製品情報
The BioFlo 320 seamlessly connects R&D to clinical and commercial manufacturing
The BioFlo 320 is compatible with a wide selection of bioreactors, providing working volumes from 400 mL to 40 L on a single platform. In combination with the BioFlo 720 bioreactor control system, the BioFlo platform supports one of the widest range of single-use solutions, allowing the scale-up of your process to up to 500 L.
• Validation Guide available to support controller qualification for manufacturing applications.
• In combination with BioBLU HNQ Single-Use Bioreactors, DASware control plus SCADA software, and service offerings for qualification and calibration, the BioFlo 320 provides a unified solution to support compliance with GMP requirements.
• Integrated Scale Up Assist software feature simplifies the calculation of important process parameters necessary to scale up and down.
• Emerson® DeltaV integration with the BioFlo 320 simplifies tech-transfer, scale-up, and recipe sharing.
The BioFlo 320 is highly configurable to meet your application needs
Advanced technical features make the BioFlo 320 a powerful tool for R&D as well as manufacturing. A high level of application flexibility is made possible by features like universal connections for analog and digital sensors, up to six integrated pumps, a highly configurable gas flow control, and compatibility with a wide range of glass and single-use bioreactors.
• Suitable for the cultivation of human and animal cells, including stem cells, as well as microbial fermentation.
• Supports batch, fed-batch, continuous, and perfusion mode.
• Suitable for many applications, including the production of cells, secreted proteins, viral vectors, plasmids, and small molecules.
Eppendorf Bioprocess Products – application in GMP regulated environment
Download document to find out which features you can expect at minimum from Eppendorf products that are deemed suitable or compatible for GMP.
The BioFlo 320 is compatible with a wide selection of bioreactors, providing working volumes from 400 mL to 40 L on a single platform. In combination with the BioFlo 720 bioreactor control system, the BioFlo platform supports one of the widest range of single-use solutions, allowing the scale-up of your process to up to 500 L.
• Validation Guide available to support controller qualification for manufacturing applications.
• In combination with BioBLU HNQ Single-Use Bioreactors, DASware control plus SCADA software, and service offerings for qualification and calibration, the BioFlo 320 provides a unified solution to support compliance with GMP requirements.
• Integrated Scale Up Assist software feature simplifies the calculation of important process parameters necessary to scale up and down.
• Emerson® DeltaV integration with the BioFlo 320 simplifies tech-transfer, scale-up, and recipe sharing.
The BioFlo 320 is highly configurable to meet your application needs
Advanced technical features make the BioFlo 320 a powerful tool for R&D as well as manufacturing. A high level of application flexibility is made possible by features like universal connections for analog and digital sensors, up to six integrated pumps, a highly configurable gas flow control, and compatibility with a wide range of glass and single-use bioreactors.
• Suitable for the cultivation of human and animal cells, including stem cells, as well as microbial fermentation.
• Supports batch, fed-batch, continuous, and perfusion mode.
• Suitable for many applications, including the production of cells, secreted proteins, viral vectors, plasmids, and small molecules.
Eppendorf Bioprocess Products – application in GMP regulated environment
Download document to find out which features you can expect at minimum from Eppendorf products that are deemed suitable or compatible for GMP.


インテリジェントな センサー
• 統合型Mettler Toledo Intelligent Sensor Management (ISM)プラットフォーム
• 最大4つのアナログ式またはデジタル式(ISM)センサーのためのユニバーサルな接続
• pH: アナログ式またはデジタル式(ISM)
• DO:アナログ式またはデジタル式(ISM)
• 光学式DO:デジタル式(ISM)
• Redox:アナログ式またはデジタル式(ISM)
• CO2:デジタル式(ISM)
• リアルタイムのセンサー診断はセンサーの故障を予測します




DASware control plusへの連結
臨床用かつ商業用製造において使用するためには、BioFlo 320 を強力なDASware control plus SCADAソフトウェアに接続することができます。
• 21 CFR Part 11とEudraLex Volume 4 Annex 11に互換性あり
• ユーザー認証とアクセスコントロール
• 電子記録と署名
DASware ソフトウェアパッケージの使用は外部センサーの統合とフィードバックループのスクリプトといったプロセスコントロールのための高度な特長を提供します。
時間節約とリスク軽減のためのAdvanced Software Solutions
• シングルユーザーインターフェースの最大8個のユニットをコントロール。
• 簡易化コントロール(4ガス、3ガス)用自動ガス混合アルゴリズム;O2エンリッチメント、N2エンリッチメント
• 洗練された制御戦略のための10ポイント
• スケード特性アラーム機能はコントローラにおけるアラーム履歴概要のステータスとアラーム発生時にEメールを送信するオプションについて自動的に通知。
• 診断画面はハードウェアステータスと予定メンテナンスについて情報を提供。
• 自動校正 – すべての接続されたDOセンサーの一度に大幅に行う自動校正は準備時間を軽減し、確かな一貫性を提供。




シームレスに洞察し、協力を促進
DASware control によって収集されたすべてのデータはBioNsight cloud ソフトウェアで切れ目なく視覚化することができます。
ユーザーがリアルタイムで運転中のプロセスを追跡、監視、リモートで分析することが可能です。
• すべての運転中プロセスをリアルタイムで監視します。
• ゴールデンバッチ運転と比較します。
• 実験室、サイト、または協力パートナーすべてのデータを共有します。
• ハイブリッドモデリングテクノロジーを活用し、重大な品質要素をより速く予測し、実験数を大幅に軽減します。




小さいフットプリント
R&D実験室からパイロットスケールの製造設備まで、スペースは正しい設備を選ぶ場合に重要な要素です。BioFlo 320はフレキシビリティ、より良い制御、最大の機能性を提供します。一方、類似システムの貴重な実験室スペースの一部を占めるだけです。従って、さらに優れた作業効率性と生産性がもたらされ、実験室の管理コストを抑えることが可能です。


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アプリケーション
- Universal bench-scale controller for cell culture and fermentation applications in R&D and clinical and commercial manufacturing
- Fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
- Cultivation of mammalian, insect, and human cell lines
- Cultivation of stem cells
- Specialized packed-bed impeller for the cultivation of anchorage and non-anchorage dependent cells, for example for vaccine process development
- Cell culture on microcarriers using specialized cell-lift impeller
- Suitable for batch, fed-batch, and continuous/perfusion processes
- Validation Guide available to support controller qualification for manufacturing applications1)
特徴
- Universal control for both microbial and cell culture applications
- Controls up to eight systems from a single user interface
- Compatible with BioBLU HNQ Single-Use Bioreactors
- Up to six integrated pumps capable of operating in variable-speed mode
- Integrated Mettler Toledo® ISM® platform
- Built-in optical pH sensing technology for use with the BioBLU HNQ Single-Use Bioreactors
- Field-upgradable TMFC drawers for sparge and overlay gas
- Eight independently controlled process gas supplies
- Enhanced software package with new cascade and time profile features
- DeltaV compatibility available through DeltaV Discovery and DeltaV ProPlus PAS
- Validation Guide available to support controller qualification for manufacturing applications.
- Compatible with 21 CFR Part 11 and EudraLex Volume 4 Annex 11 compatible DASware control plus SCADA software
ダウンロード: BioFlo® 320 for commercial manufacturing
同時にご考慮下さい。