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- Challenges and Chances: A Review of the 1st Stem Cell Community Day
- Summertime, and the Livin’ Is Easy…
- Follow-on-Biologics – More than Simple Generics
- Bacteria Versus Body Cells: A 1:1 Tie
- Behind the Crime Scene: How Biological Traces Can Help to Convict Offenders
- Every 3 Seconds Someone in the World Is Affected by Alzheimer's
- HIV – It’s Still Not Under Control…
- How Many Will Be Convicted This Time?
- Malaria – the Battle is Not Lost
- Physicians on Standby: The Annual Flu Season Can Be Serious
- At the Forefront in Fighting Cancer
- Molecular Motors: Think Small and yet Smaller Again…
- Liquid Biopsy: Novel Methods May Ease Cancer Detection and Therapy
- They Are Invisible, Sneaky and Disgusting – But Today It’s Their Special Day!
- How Many Cells Are in Your Body? Probably More Than You Think!
- What You Need to Know about Antibiotic Resistance – Findings, Facts and Good Intentions
- Why Do Old Men Have Big Ears?
- The Condemned Live Longer: A Potential Paradigm Shift in Genetics
- From Research to Commerce
- Chronobiology – How the Cold Seasons Influence Our Biorhythms
- Taskforce Microbots: Targeted Treatment from Inside the Body
- Eyes on Cancer Therapy
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- Challenges and Chances: A Review of the 1st Stem Cell Community Day
- Summertime, and the Livin’ Is Easy…
- Follow-on-Biologics – More than Simple Generics
- Bacteria Versus Body Cells: A 1:1 Tie
- Behind the Crime Scene: How Biological Traces Can Help to Convict Offenders
- Every 3 Seconds Someone in the World Is Affected by Alzheimer's
- HIV – It’s Still Not Under Control…
- How Many Will Be Convicted This Time?
- Malaria – the Battle is Not Lost
- Physicians on Standby: The Annual Flu Season Can Be Serious
- At the Forefront in Fighting Cancer
- Molecular Motors: Think Small and yet Smaller Again…
- Liquid Biopsy: Novel Methods May Ease Cancer Detection and Therapy
- They Are Invisible, Sneaky and Disgusting – But Today It’s Their Special Day!
- How Many Cells Are in Your Body? Probably More Than You Think!
- What You Need to Know about Antibiotic Resistance – Findings, Facts and Good Intentions
- Why Do Old Men Have Big Ears?
- The Condemned Live Longer: A Potential Paradigm Shift in Genetics
- From Research to Commerce
- Chronobiology – How the Cold Seasons Influence Our Biorhythms
- Taskforce Microbots: Targeted Treatment from Inside the Body
- Eyes on Cancer Therapy
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JP | JPY
Webinar
Increasing Upstream Bioprocessing Efficiency through Process Analytical Technology
Lab Academy
Here we present strategies for in line process analytics that aimed at automated feed control in an upstream bioprocess.
In biologics production, the upstream bioprocess contributes significantly to product quality and manufacturing efficiency. A comprehensive understanding on which process parameters are critical and how they influence process outcome allows the development of tailored control strategies and, as a result, achieving consistent process performance.
Compared to offline measurements in a sample that has been taken from the bioreactor, inline analysis of process parameters reduces the manual workload and facilitates the implementation of automated feedback control loops. While inline analytics of some process parameters, such as temperature, DO, and pH is well established, real-time measurement of others, such as metabolite concentrations or cell viability is not yet routine.
Here we present strategies for in line process analytics that aimed at automated feed control in an upstream bioprocess. Using the example of a Raman analyzer, a glucose analyzer, and an exhaust analyzer we demonstrate, how to achieve seamless sensor integration with the bioprocess control software. In all cases we met the challenge of keeping the glucose concentration stable during the bioprocess run and minimize human intervention.
Dr. Joerg Schwinde, Eppendorf AG – Bioprocess Center, Juelich, Germany
Compared to offline measurements in a sample that has been taken from the bioreactor, inline analysis of process parameters reduces the manual workload and facilitates the implementation of automated feedback control loops. While inline analytics of some process parameters, such as temperature, DO, and pH is well established, real-time measurement of others, such as metabolite concentrations or cell viability is not yet routine.
Here we present strategies for in line process analytics that aimed at automated feed control in an upstream bioprocess. Using the example of a Raman analyzer, a glucose analyzer, and an exhaust analyzer we demonstrate, how to achieve seamless sensor integration with the bioprocess control software. In all cases we met the challenge of keeping the glucose concentration stable during the bioprocess run and minimize human intervention.
Key Learning Objectives:
- Get to know, how inline process analytics can improve bioprocess efficiency
- Learn, which bioreactor software features are needed to integrate analyzers and to implement automated feedback control loops
- Benefit from hands-on experience in integrating analyzers to automate culture feeding
Duration : 35 minutes
Speakers
Dr. Joerg Schwinde, Eppendorf AG – Bioprocess Center, Juelich, Germany
Register and watch recordings now!
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